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Medical Council of Canada MCCQE Part 1 Exam Sample Questions (Q350-Q355):

NEW QUESTION # 350
An 18-month-old boy is brought to the office by his guardians for a well-child visit. His guardians are concerned that his eyes do not look the same. On examination, his eyes appear as shown in the referenced photo.
Which one of the following best represents the patient's condition?

Answer: A

Explanation:
The image shows an asymmetrical light reflex (corneal light reflex not centered in both eyes), which is diagnostic of strabismus. This misalignment of the eyes must be treated early to prevent amblyopia (lazy eye).
Toronto Notes 2023 - Pediatrics, Ophthalmology:
"Strabismus presents with misaligned visual axes. The Hirschberg light reflex is off-center in the affected eye.
Prompt referral is necessary to prevent amblyopia."
MCCQE1 Objectives - Pediatrics > Vision and Developmental Disorders:
"Candidates must recognize strabismus on visual screening and refer early for correction to prevent permanent vision impairment." Pseudostrabismus (B) can be ruled out here because the light reflex is not symmetric. Ptosis (A) involves drooping of the eyelid, which is not evident. Cataracts (D) would typically present with a leukocoria (white reflex), not misalignment.


NEW QUESTION # 351
A 72-year-old man presents to your clinic with worsening lower leg edema. He has hypertension, type 2 diabetes, and a history of heavy drinking. On examination, he is pale and has a BMI of 35. Vital signs are as follows:
Blood pressure: 110/60 mm Hg
Heart rate: 102/min
Temperature: Afebrile
His jugular venous pressure is 4 cm above the sternal angle. Cardiac auscultation is normal, and his lungs are clear. His liver is not palpable; he has abdominal distension, bulging flanks, and pitting edema below the knees. While awaiting test results, which one of the following is the best next step?

Answer: B

Explanation:
This patient has signs suggestive of decompensated liver cirrhosis (ascites, peripheral edema, low-normal BP, alcohol use, abdominal distension). Sodium restriction is the cornerstone of first-line management to prevent fluid retention in cirrhotic ascites.
Toronto Notes 2023 - Gastroenterology, "Cirrhosis and Ascites" Section:
"Sodium restriction (<2 g/day) is the most important non-pharmacologic management for ascites. Fluid restriction is added only in cases of severe hyponatremia." MCCQE1 Objectives (Internal Medicine > 76-5: Liver Disease):
"Candidates must manage ascites conservatively using sodium restriction, with diuretics added as needed." Lactulose (E) is used for hepatic encephalopathy, not ascites. Ramipril (B) may worsen renal function in cirrhosis. Nadolol (C) is used for variceal bleeding prophylaxis. Compression stockings (D) are not helpful in ascites-related edema.


NEW QUESTION # 352
A 19-year-old woman presents to the office. She is a new mother. She shares that she does not intend to vaccinate her son. Which one of the following is the best next step?

Answer: C

Explanation:
When encountering vaccine hesitancy, the first and most effective step is to open a non-judgmental conversation and explore the patient's reasons. This helps build trust and tailor subsequent education and counseling.
Toronto Notes 2023 - Public Health and Preventive Medicine, Immunization:
"Addressing vaccine hesitancy requires understanding parental concerns. Begin with open-ended questions to identify underlying beliefs and information gaps." MCCQE1 Objectives - Preventive Medicine > Immunization:
"Candidates must demonstrate effective communication with vaccine-hesitant parents, beginning with eliciting their rationale before providing evidence-based recommendations." Jumping to education (B) or punitive measures (C, D) may close communication. The patient is an adult; speaking with her parents (E) violates her autonomy.


NEW QUESTION # 353
While covering for a colleague away on holidays, you receive the following laboratory results for one of her patients, a 24-year-old woman:
White blood cell count: 10 × 10#/L (4-10)
Hemoglobin: 80 g/L (123-157)
Mean corpuscular volume: 76 fL (80-100)
Platelet count: 150 × 10#/L (130-400)
You have arranged a follow-up appointment for the patient with your colleague. Which one of the following is the most likely diagnosis?

Answer: D

Explanation:
These results show a significant anemia (Hb 80 g/L) with microcytosis (MCV 76 fL) and otherwise preserved cell lines (WBC at the upper end of normal; platelets normal). MCCQE objectives emphasize using CBC patterns to classify anemia and prioritize common causes. In a young woman, the most likely cause of microcytic anemia is iron deficiency , most often due to menstrual blood loss and/or inadequate iron intake, and it can be severe.
Leukemia and myelodysplasia typically present with abnormalities in multiple cell lines (e.g., leukocytosis with blasts or cytopenias) and are less consistent with an isolated microcytic anemia and normal platelets.
Anemia of chronic disease is usually normocytic or mildly microcytic and is less likely to produce such a low hemoglobin without an obvious chronic inflammatory condition. Thalassemia trait classically has marked microcytosis with relatively preserved hemoglobin (often only mild anemia) and is suggested by a lifelong history and family/ethnic background. The next clinical step (at follow-up) would be iron studies (ferritin first) and assessment for bleeding sources.


NEW QUESTION # 354
An 8-year-old boy is brought to the Emergency Department because he is experiencing sudden respiratory distress. You suspect that he has a spontaneous tension pneumothorax. On physical examination, which one of the following best supports this diagnosis?

Answer: B

Explanation:
A tension pneumothorax occurs when air enters the pleural space and cannot escape, creating progressively rising intrathoracic pressure. MCCQE objectives emphasize rapid recognition of life-threatening causes of respiratory distress based on bedside findings. As pressure builds, the affected hemithorax compresses the lung and pushes the mediastinum to the opposite side, producing tracheal deviation away from the affected side -a classic, high-specificity sign of tension physiology (often accompanied by severe dyspnea, tachycardia, unilateral absent breath sounds, hyperresonance, distended neck veins, and hypotension from impaired venous return).
The other options do not specifically support tension pneumothorax: ecchymoses suggest trauma; bilateral wheezing suggests asthma or bronchiolitis; abdominal distension is nonspecific; inspiratory stridor indicates upper airway obstruction (e.g., croup, foreign body). Because tension pneumothorax is a clinical diagnosis, MCCQE priorities are immediate decompression (needle thoracostomy) followed by chest tube placement- without waiting for imaging if the child is unstable.


NEW QUESTION # 355
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